Drug Abuse Handbook, Second Edition

Drug Abuse Handbook, Second Edition

Language: English

Pages: 1288

ISBN: 0849316901

Format: PDF / Kindle (mobi) / ePub


Following the well-received first edition, the Drug Abuse Handbook, Second Edition is a thorough compendium of the knowledge of the pharmacological, medical, and legal aspects of drugs. The book examines criminalistics, pathology, pharmacokinetics, neurochemistry, treatment, as well as drugs and drug testing in the workplace and in sports, and the ethical, legal, and practical issues involved.

Dr. Karch gathers contributions from 80 leading experts in their respective fields to update and revise this second edition with more than 40 percent new material. New topics include genetic testing in drug death investigation, the neurochemistry of nicotine and designer amphetamines, genetic doping in sports, and the implications of the Daubert ruling on the admissibility of scientific evidence in federal court.

Packed with the latest information in an easily accessible format, the book includes tables of all Scheduled Drugs, methods of Drug Quantitative Analysis, and a glossary of forensic toxicology terms. Vivid pictures and diagrams illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. It includes more than 6000 references to the best sources in medicine, pharmacology, and the law.

This book addresses specific problems in drug testing, drug-related medical emergencies, and the physical, neurochemical, and sociological phenomenon of addiction. With unparalleled detail and the highest level of authoritative information, The Drug Abuse Handbook, Second Edition is the definitive resource for drug related issues.

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form p-hydroxyphenobarbital followed by conjugation with glucuronic acid (Figure 3.6.5). A dihydrohydroxy metabolite has been identified in minor amounts, thought to arise from an epoxide intermediate.11 Approximately 80% of a single labeled dose is excreted in the urine within 16 days. Unchanged drug accounts for 25 to 33% of the dose, N-glucosyl-phenobarbital for 24 to 30%, and free or conjugated p-hydroxyphenobarbital for 18 to 19%.12 When administered chronically, approximately 25% of the

(PCPy), and 1-[1-(2-thienyl-cyclohexyl)]-piperidine (TCP). In the 1960s, PCP was distributed as a white to off-white powder or crystalline material and ingested orally. In recent years, PCP has been encountered as the base and dissolved in diethyl ether. The liquid is then placed into small bottles which are recognized to hold © 1998 by CRC Press LLC Figure 1.4.7 Synthetic routes utilized for illegal production of PCP. commercial vanilla extract. This ether solution is then sprayed on leaves

evident in all cases.41 Lymphocytic infiltrates were seen in only two of the cases, and eosinophils were not seen at all. Identical changes have been described in chronic amphetamine abusers.51 Because contraction band necrosis is a prominent feature of all myocardial biopsies, regardless of the underlying cause, the presence of these lesions in biopsy material is difficult, but not impossible, to assess.52 The presence of nuclear pyknosis in damaged cells may be one way to distinguish

that necrosis was very severe . The first reports of contraction band-like lesions and cellular infiltrates in the heart of a cocaine users were published in the 1920s!53 However, more than half a century elapsed before another paper, describing similar findings, was published in 1986.54 A biopsy of one of the cocaine users described in that report disclosed eosinophilic infiltrates. Others have observed both lymphocytic and eosinophilic interstitial infiltrates.46,47,55–58 More often than not,

patients. Am Heart J 1988;115(5):1068-1076. 57. Talebzadeh V, Chevrolet J, Chatelain P, et al. Myocardite à éosinophiles et hypertension pulmonaire chez une toxicomane. Ann Pathol 1990;10(1):40-46. 58. Turnicky R, Goodin J, Smialek J, et.al. Incidental myocarditis with intravenous drug abuse. The pathology, immunopathology, and potential implications for human immunodeficiency virusassociated myocarditis. Hum Pathol 1992;23:138-143. 59. Aretz H, Billingham M, Edwards W, et al. Myocarditis: a

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