HIV/AIDS Treatment Drugs (Understanding Drugs)

HIV/AIDS Treatment Drugs (Understanding Drugs)

Brigid M. Kane

Language: English

Pages: 155

ISBN: 1604135417

Format: PDF / Kindle (mobi) / ePub

HIV/AIDS Treatment Drugs explains how HIV functions and describes the drugs used to treat HIV infection, how they work and are combined, how HIV drugs are developed, and what new treatments are being investigated.

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with all the genetic information needed for the virus to replicate itself, and with all three enzymes to make replication happen inside a host cell: reverse transcriptase, integrase, and protease.25 These enzymes are indispensable to viral replication and the contin- ued infection of additional susceptible cells. Therefore, these enzymes are the perfect targets for HIV/AIDS medicines. If one or more of these enzymes were knocked out or crippled, HIV would not be able to hold its offensive

for use in AIDS patients targeted a viral enzyme essential to the virus’s survival—reverse transcriptase. Theoretically, these drugs could stop HIV in its tracks by disabling the enzyme responsible for the chemical reaction that produces viral DNA molecules (a necessary first step for the propagation of new virions). That was the theory. In reality, although reverse transcriptase inhibitors do disrupt the reverse transcription process, they do not do enough damage by themselves at doses

Kornfeld, J. Gold, J. Hassett, S.Z. female sexual partners of Hirschman, C. Cunningham- males with Acquired Immune Rundles, B.R. Adelsberg, et al. Deficiency Syndrome (AIDS)— “Severe acquired immunode- New York,” Morbidity & ficiency in male homosexuals, Mortality Weekly Report 31, 52 manifested by chronic peri- (January 7, 1983): 697-698. anal ulcerative herpes simplex 12. Shilts, Randy. And the Band lesions,” New England Journal of Played On: Politics, People, and 99 Endnotes

74 50–51, 88, 105 epidemiologists, 28, 105 gp120, 34, 74 cross-resistance, 55 Epivir. See lamivudine gp120 envelope protein, 73 DRV. See darunavir Epzicom. See abacavir/ grapefruit juice, and drug lamivudine interactions, 62 efavirenz (EFV), 55, etravirine (TMC125), GRID. See gay-related 56–57, 57 57–58 immune deficiency in combination treat- European AIDS Clinical GS-9137 (eltigravir), 68 ment, 81 Society, 82 GSK364735, 68 in DHHS treatment experimental names, of

through filters capable of trapping bacteria. The Russian scientist Dmitri Ivanovski discovered these “filterable viruses” in the laboratory in 1892. Actually, Ivanovski didn’t know whether he had isolated a substance, such as a toxin, or a life form smaller than bacteria; he only knew that whatever was causing disease in tobacco plants could pass through pores in a filter through which bacteria could not. Six years later, the Dutch scientist Martinus Bei- jerinck reproduced Ivanovski’s

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